Article
Potential impact of viral load and genetic makeup of HIV type 1 on mother-to-child transmission: characterization of env-C2V3C3 and nef sequences.
AIDS research and human retroviruses - 1 Nov 2009
Pádua Elizabeth, Parreira Ricardo, Tendeiro Rita, Nunes Baltazar, Castela João, Soares Isabel, Mouzinho Ana, Reis Eduarda, Paixão Maria Teresa
Abstract excerpt
HIV-1 mother-to-child transmission (MTCT) was evaluated in terms of the molecular characterization of the env and nef genomic regions and quantification of maternal RNA viral loads. Assignment of viral subtype was achieved by direct sequencing of PCR 1172 products amplified from proviral DNA in 45 HIV-1-nontransmitting mothers (NTM), along with 13 pairs of HIV-1-transmitting mothers (TM) and their infected...
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