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Article

Retinal degeneration-3 protein attenuates photoreceptor degeneration in transgenic mice expressing dominant mutation of human retinal guanylyl cyclase.

The Journal of biological chemistry - 1 Oct 2021

Peshenko Igor V, Olshevskaya Elena V, Dizhoor Alexander M

Abstract excerpt

Different forms of photoreceptor degeneration cause blindness. Retinal degeneration-3 protein (RD3) deficiency in photoreceptors leads to recessive congenital blindness. We proposed that aberrant activation of the retinal membrane guanylyl cyclase (RetGC) by its calcium-sensor proteins (guanylyl cyclase-activating protein [GCAP]) causes this retinal degeneration and that RD3 protects photoreceptors by preventing...

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Identifiers

PMID: 34537244
DOI: 10.1016/j.jbc.2021.101201
PMCID: PMC8517212

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Retinal degeneration-3 protein attenuates photoreceptor degeneration in transgenic mice expressing dominant mutation of human retinal guanylyl cyclase.PMID 34537244Read ↗

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