Article
p21WAF-1 reorganizes the nucleus in tumor suppression.
Proceedings of the National Academy of Sciences of the United States of America - 3 Feb 1998
Linares-Cruz G, Bruzzoni-Giovanelli H, Alvaro V, Roperch J P, Tuynder M, Schoevaert D, Nemani M, Prieur S, Lethrosne F, Piouffre L, Reclar V, Faille A, Chassoux D, Dausset J, Amson R B, Calvo F, Telerman A
Abstract excerpt
Interphasic nuclear organization has a key function in genome biology. We demonstrate that p21WAF-1, by influencing gene expression and inducing chromosomal repositioning in tumor suppression, plays a major role as a nuclear organizer. Transfection of U937 tumor cells with p21WAF-1 resulted in expression of the HUMSIAH (human seven in absentia homologue), Rb, and Rbr-2 genes and strong suppression of the...
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