Article
Incorporating genotypes of relatives into a test of linkage disequilibrium.
American journal of human genetics - 1 Jan 1998
Excoffier L, Slatkin M
Abstract excerpt
Genetic data from autosomal loci in diploids generally consist of genotype data for which no phase information is available, making it difficult to implement a test of linkage disequilibrium. In this paper, we describe a test of linkage disequilibrium based on an empirical null distribution of the likelihood of a sample. Information on the genotypes of related individuals is explicitly used to help reconstruct...
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