Genetics of prions.

doi:10.1146/annurev.genet.31.1.139

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Article

Genetics of prions.

Annual review of genetics - 1 Jan 1997

Prusiner S B, Scott M R

Abstract excerpt

Prions are unprecedented infectious pathogens that cause a group of invariably fatal, neurodegenerative diseases by an entirely novel mechanism. Prion diseases may present as genetic, infectious, or sporadic disorders, all of which involve modification of the prion protein (PrP). The human prion disease Creutzfeldt-Jakob disease (CJD) generally presents as a progressive dementia, whereas scrapie of sheep and...

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PMID: 9442893
DOI: 10.1146/annurev.genet.31.1.139

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