Article
Association of cyclin-dependent kinase 5 and its activator p35 with apoptotic cell death.
Developmental genetics - 1 Jan 1997
Ahuja H S, Zhu Y, Zakeri Z
Abstract excerpt
We have investigated the role of cyclin-dependent kinases in cell death and found that the expression of cyclin-dependent kinase 5 (Cdk5) is associated with apoptotic cell death in both adult and embryonic tissues. By double labeling immunohistochemistry and confocal microscopy, we specifically associated the expression of Cdk5 to dying cells. The association of Cdks with cell death is unique to Cdk5 as this...
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