Article
Menin mutations in the diagnosis and prediction of multiple endocrine neoplasia type 1.
Langenbeck's archives of surgery - 1 Apr 1998
Karges W, Ludwig L, Kessler H, Wissmann A, Wagner P K, Boehm B O
Abstract excerpt
INTRODUCTION: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized by the development of multiple endocrine adenomas, typically in the pancreas, anterior pituitary, and parathyroid glands. The disease is associated with germ-line mutations of the menin gene, a putative tumor-suppressor gene located on human chromosome 11q13. METHODS: To facilitate the diagnosis and prediction...
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