Article
Menin mutations in the diagnosis and prediction of multiple endocrine neoplasia type 1.
Langenbeck's archives of surgery - 1 Apr 1998
Karges W, Ludwig L, Kessler H, Wissmann A, Wagner P K, Boehm B O
Abstract excerpt
INTRODUCTION: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized by the development of multiple endocrine adenomas, typically in the pancreas, anterior pituitary, and parathyroid glands. The disease is associated with germ-line mutations of the menin gene,...
Topics
- Adult
- Chromosome Aberrations
- Chromosome Deletion
- Chromosome Disorders
- Chromosomes, Human, Pair 11
- DNA Mutational Analysis
- Female
- Genes, Dominant
- Genetic Carrier Screening
- Genetic Testing
- Humans
- Male
- Middle Aged
- Multiple Endocrine Neoplasia Type 1
- Mutation
- Neoplasm Proteins
- Pedigree
- Polymerase Chain Reaction