Article
Creation of an isogenic P1-deficient mutant of Haemophilus influenzae biogroup aegyptius.
Gene - 19 Dec 1997
Segada L M, Lesse A J
Abstract excerpt
Haemophilus influenzae biogroup aegyptius, the causative agent of Brazilian purpuric fever (BPF), expresses a heat-modifiable 48 kDa outer membrane protein, P1, which is conserved in most Brazilian case-clone isolates. To study the role of P1 in pathogenesis of BPF we constructed via homologous recombination an isogenic P1-deficient mutant of H. influenzae biogroup aegyptius. The procedure involved a modification...
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