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Article

Tracing phylogenomic events leading to diversity of Haemophilus influenzae and the emergence of Brazilian Purpuric Fever (BPF)-associated clones.

Genomics - 1 Nov 2010

Papazisi Leka, Ratnayake Shashikala, Remortel Brian G, Bock Geoffrey R, Liang Wei, Saeed Alexander I, Liu Jia, Fleischmann Robert D, Kilian Mogens, Peterson Scott N

Abstract excerpt

Here we report the use of a multi-genome DNA microarray to elucidate the genomic events associated with the emergence of the clonal variants of Haemophilus influenzae biogroup aegyptius causing Brazilian Purpuric Fever (BPF), an important pediatric disease with a high mortality rate. We performed directed genome sequencing of strain HK1212 unique loci to construct a species DNA microarray. Comparative genome...

Topics

Bacterial Proteins
Brazil
Comparative Genomic Hybridization
Fever
Genetic Variation
Genome, Bacterial
Haemophilus Infections
Haemophilus influenzae
Humans
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligonucleotide Array Sequence Analysis

Phylogeny

Purpura

Sequence Analysis, DNA

Virulence Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 20654709
DOI: 10.1016/j.ygeno.2010.07.005
PMCID: PMC2967034

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