Article
Genetic control of diabetes progression.
Immunity - 1 Dec 1997
Gonzalez A, Katz J D, Mattei M G, Kikutani H, Benoist C, Mathis D
Abstract excerpt
Autoimmune diabetes in both the human and the nonobese diabetic mouse has elaborate genetics; in the latter case, the disease is influenced by at least 15-20 loci. We anticipated that the genetics would be simpler in the BDC2.5 T cell receptor transgenic mouse model of diabetes, wherein many T cells express a particular diabetogenic specificity. Initiation of insulitis in this model was the same on the two...
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