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Article

Interaction of Angeli's salt with cytochrome P450 1A2 distal mutants: an optical absorption spectral study.

Biochimica et biophysica acta - 14 Nov 1997

Shibata Y, Sato H, Sagami I, Shimizu T

Abstract excerpt

Angeli's salt, Na2N2O3 or O-N=N+-(OH)(O-) in aqueous solution, is known to release NO- or NO., which relaxes vascular tissue and lowers blood pressure. In the liver, the most abundant heme enzyme is cytochrome P450. In the present study, we studied the effect of rat liver cytochrome P450 1A2 (P450 1A2) in regard to its catalysis of the N=N bond scission of Angeli's salt with optical absorption spectra. Also, we...

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PMID: 9428660
DOI: 10.1016/s0167-4838(97)00104-0

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