ras transformation is associated with decreased expression of the brm/SNF2alpha ATPase from the mammalian SWI-SNF complex.

doi:10.1093/emboj/17.1.223

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Article

ras transformation is associated with decreased expression of the brm/SNF2alpha ATPase from the mammalian SWI-SNF complex.

The EMBO journal - 2 Jan 1998

Muchardt C, Bourachot B, Reyes J C, Yaniv M

Abstract excerpt

The brm and BRG-1 proteins are mutually exclusive subunits of the mammalian SWI-SNF complex. Within this complex, they provide the ATPase activity necessary for transcriptional regulation by nucleosome disruption. Both proteins were recently found to interact with the p105Rb tumor suppressor gene...

Topics

3T3 Cells
Adenosine Triphosphatases
Animals
Cell Transformation, Neoplastic
Down-Regulation
Gene Expression Regulation
Genes, ras
HeLa Cells
Humans
Mice
Mitogens
Oncogenes
Phenotype
Transcription Factors

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