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Article

ras transformation is associated with decreased expression of the brm/SNF2alpha ATPase from the mammalian SWI-SNF complex.

The EMBO journal - 2 Jan 1998

Muchardt C, Bourachot B, Reyes J C, Yaniv M

Abstract excerpt

The brm and BRG-1 proteins are mutually exclusive subunits of the mammalian SWI-SNF complex. Within this complex, they provide the ATPase activity necessary for transcriptional regulation by nucleosome disruption. Both proteins were recently found to interact with the p105Rb tumor suppressor gene product, suggesting a role for the mammalian SWI-SNF complex in the control of cell growth. We show here that the...

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Identifiers

PMID: 9427756
DOI: 10.1093/emboj/17.1.223
PMCID: PMC1170373

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