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Contribution of BRG1-dependent SWI/SNF complexes to determining the phenotype of cancer cell

Postepy biochemii - 31 Mar 2020

Sobczak Maciej, Strachowska Magdalena, Robaszkiewicz Agnieszka

Abstract excerpt

ATP-dependent chromatin remodeling complexes are documented as indispensible element of epigenetic mechanisms, which control transcription. These multiprotein functional units are capable of insertion, deletion and sliding of nucleosomes at the gene regulatory elements thereby defining DNA accessibility to transcription machinery. SWI/SNF is one out of four identified and described complexes. The enzymatic role...

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PMID: 33320476
DOI: 10.18388/pb.2020_312

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