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Article

Microevolution of a Standard Strain ofCryptococcus neoformansResulting in Differences in Virulence and Other Phenotypes

1 Jan 1998

Abstract excerpt

Cryptococcus neoformans is a major fungal pathogen for patients with debilitated immune systems. However, no information is available on the stability of virulence or of phenotypes associated with virulence for C. neoformans laboratory strains. A serendipitous observation in our laboratory that one isolate of C. neoformans ATCC 24067 (strain 52D) became attenuated after continuous in vitro culture prompted us to...

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PMID: 9423844
DOI: 10.1128/iai.66.1.89-97.1998

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