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Evaluation of phenotypic and genotypic alterations induced by long periods of subculturing of Cryptococcus neoformans strains.

Memorias do Instituto Oswaldo Cruz - 1 Feb 2007

Cavalcante Sonia Cristina, Freitas Roseli Santos, Vidal Mônica Scarpelli Martinelli, Dantas Kátia Cristina, Levi José Eduardo, Martins José Eduardo Costa

Abstract excerpt

Cryptococcus neoformans is an encapsulated fungal organism that can cause disease in apparently immunocompetent, as well as immunocompromised, hosts. Since 1930, successive subculture has been used to preserve C. neoformans isolates in our Fungus Collection. In the 1970s, some of these Fungus Collection samples were selected to be subjected to a different methods of maintenance--that of lyophilized. Our objective...

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PMID: 17293997
DOI: 10.1590/s0074-02762007000100006

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