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Article

Proliferation of human malignant astrocytomas is dependent on Ras activation.

Oncogene - 4 Dec 1997

Guha A, Feldkamp M M, Lau N, Boss G, Pawson A

Abstract excerpt

Overexpression and activation of receptor tyrosine kinases, such as platelet derived growth factor receptors (PDGFRs) and epidermal growth factor receptor (EGFR), leads to proliferation of human malignant astrocytoma cells. Although oncogenic mutations affecting Ras are not prevalent in human malignant astrocytomas, we have investigated whether levels of activated Ras.GTP might be elevated in these tumors...

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Source

Identifiers

PMID: 9419966
DOI: 10.1038/sj.onc.1201455

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Proliferation of human malignant astrocytomas is dependent on Ras activation.PMID 9419966Read ↗

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