Proliferation of human malignant astrocytomas is dependent on Ras activation.

doi:10.1038/sj.onc.1201455

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Article

Proliferation of human malignant astrocytomas is dependent on Ras activation.

Oncogene - 4 Dec 1997

Guha A, Feldkamp M M, Lau N, Boss G, Pawson A

Abstract excerpt

Overexpression and activation of receptor tyrosine kinases, such as platelet derived growth factor receptors (PDGFRs) and epidermal growth factor receptor (EGFR), leads to proliferation of human malignant astrocytoma cells. Although oncogenic mutations affecting Ras are not prevalent in human mal...

Topics

Alkyl and Aryl Transferases
Astrocytoma
Brain
Calcium-Calmodulin-Dependent Protein Kinases
Cell Division
ErbB Receptors
Farnesyltranstransferase
Genes, ras
Guanosine Triphosphate
Humans
Mutation
Receptors, Platelet-Derived Growth Factor
Signal Transduction
Tumor Cells, Cultured
Up-Regulation
ras Proteins

Source

Open in PubMed

Identifiers

PMID: 9419966
DOI: 10.1038/sj.onc.1201455

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9419966-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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