Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Coexpression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintenance.

1 Jul 1990

Abstract excerpt

The present studies investigated the expression of the two PDGF genes (c-sis/PDGF-2 and PDGF-1) and the PDGF-receptor b gene (PDGF-R) in 34 primary human astrocytomas. Northern blot analysis demonstrated the coexpression of the c-sis/PDGF-2 protooncogene and the PDGF-R gene in all astrocytomas examined. The majority of the tumors also expressed the PDGF-1 gene. There was no correlation between the expression of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glioma Diagnosis and Treatment
Share to Neuroblastoma Research and Treatments
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 2164040
DOI: 10.1172/jci114675

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Coexpression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintenance.PMID 2164040Read ↗

Human meningiomas co‐express platelet‐derived growth factor (pdgf) and pdgf‐receptor genes and their protein productsSemantic proximity Read ↗

Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loopSemantic proximity Read ↗

Growth factor PDGF-B/v-sis confers a tumorigenic phenotype to human tumor cells bearing PDGF receptors but not to cells devoid of receptors: evidence for an autocrine, but not a paracrine, mechanism.Semantic proximity Read ↗

Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells.Semantic proximity Read ↗

Pathogenetic significance and possibility as a therapeutic target of platelet derived growth factorSemantic proximity Read ↗

Platelet-derived growth factor-B/v-sis confers a tumorigenic and metastatic phenotype to human T98G glioblastoma cells.Semantic proximity Read ↗

Autocrine PDGF stimulation in malignancies.Semantic proximity Read ↗

Molecular characterization of PDGFR-alpha/PDGF-A and c-KIT/SCF in gliosarcomas.Semantic proximity Read ↗

The Characteristics of Astrocytomas and Oligodendrogliomas Are Caused by Two Distinct and Interchangeable Signaling FormatsSemantic proximity Read ↗

Human neuroblastoma cells express alpha and beta platelet-derived growth factor receptors coupling with neurotrophic and chemotactic signaling.Semantic proximity Read ↗

Platelet‐derived growth factor in human gliomaSemantic proximity Read ↗

Recent Insights into PDGF‐Induced GliomagenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.