Article
Natural variation in neuron number in mice is linked to a major quantitative trait locus on Chr 11.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jan 1998
Williams R W, Strom R C, Goldowitz D
Abstract excerpt
Common genetic polymorphisms-as opposed to rare mutations-generate almost all heritable differences in the size and structure of the CNS. Surprisingly, these normal variants have not previously been mapped or cloned in any vertebrate species. In a recent paper (), we suggested that much of the va...
Topics
- Animals
- Biological Evolution
- Cell Count
- Chromosome Mapping
- Female
- Genetic Linkage
- Genetic Variation
- Genotype
- Male
- Mice
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Optic Nerve
- Organ Size
- Phenotype
- Polymorphism, Genetic
- Quantitative Trait, Heritable