Article
Genetic modulation of horizontal cell number in the mouse retina.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jun 2011
Whitney Irene E, Raven Mary A, Ciobanu Daniel C, Poché Ross A, Ding Qian, Elshatory Yasser, Gan Lin, Williams Robert W, Reese Benjamin E
Abstract excerpt
Neuronal populations display conspicuous variability in their size among individuals, but the genetic sources of this variation are largely undefined. We demonstrate a large and highly heritable variation in neuron number within the mouse retina, affecting a critical population of interneurons, the horizontal cells. Variation in the size of this population maps to the distal end of chromosome (Chr) 13, a region...
Topics
- 5' Untranslated Regions
- Animals
- Cell Count
- Embryo, Mammalian
- Female
- Fluorescent Antibody Technique
- Follistatin
- Gene Expression Regulation, Developmental
- Homeodomain Proteins
- LIM-Homeodomain Proteins
- Male
- Mice
- Mice, Inbred C57BL