Article
Genotype-specific transcriptional regulation of PAI-1 expression by hypertriglyceridemic VLDL and Lp(a) in cultured human endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 1997
Li X N, Grenett H E, Benza R L, Demissie S, Brown S L, Tabengwa E M, Gianturco S H, Bradley W A, Fless G M, Booyse F M
Abstract excerpt
The hypothesized relationships between plasminogen activator inhibitor (PAI-1) genotypes, PAI-1 levels, and their potential regulation by hypertriglyceridemic (HTG) very low density lipoprotein (VLDL) and lipoprotein(a) [Lp(a)] was examined in a PAI-1 genotyped human umbilical vein endothelial cell (HUVEC) culture model system. Individual human umbilical veins were used to obtain cultured ECs and were genotyped...
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