Article
The CYP2D6 genotype and plasma concentrations of mianserin enantiomers in relation to therapeutic response to mianserin in depressed Japanese patients.
Journal of clinical psychopharmacology - 1 Dec 1997
Mihara K, Otani K, Tybring G, Dahl M L, Bertilsson L, Kaneko S
Abstract excerpt
The relationship between therapeutic response to racemic mianserin and steady-state plasma concentrations of S(+)- and R(-)-mianserin was studied in 26 Japanese patients with major depression. The daily dose of mianserin was 30 mg, and the duration of treatment was 3 weeks. Regarding S-mianserin,...
Topics
- Adult
- Antidepressive Agents, Second-Generation
- Cytochrome P-450 CYP2D6
- Depressive Disorder
- Female
- Genotype
- Humans
- Japan
- Male
- Mianserin
- Middle Aged
- Stereoisomerism