[Genetics and brain gliomas].

Abstract excerpt

Chromosome arms 1p and 19q codeletion, corresponding to an unbalanced reciprocal translocation t(1;19)(q10;p10), is seen in oligodendroglial tumours and is associated with better prognosis and better chemosensitivity. BRAF abnormalities are observed in pilocytic astrocytomas (tandem duplication-rearrangement) and in pleomorphic xanthoastrocytomas (BRAF V600E mutation). The vast majority of primary or de novo...

Topics

• Astrocytoma
• Brain Neoplasms
• Cell Transformation, Neoplastic
• Chromosomes, Human, Pair 19
• Genes, Neoplasm
• Genetic Predisposition to Disease
• Germ-Line Mutation
• Glioblastoma
• Glioma
• Humans
• Intracellular Signaling Peptides and Proteins
• Mutation
• Neoplasm Proteins
• Neoplastic Syndromes, Hereditary