Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human lipooligosaccharide IGG that prevents endemic meningococcal disease recognizes an internal lacto-N-neotetraose structure.

The Journal of biological chemistry - 23 Dec 2011

Cheng Hui, Yang Zhijie, Estabrook Michele M, John Constance M, Jarvis Gary A, McLaughlin Stephanie, Griffiss J McLeod

Abstract excerpt

Antibodies that initiate complement-mediated killing of Neisseria meningitidis as they enter the bloodstream from the oropharynx protect against disseminated disease. Human IgGs that bind the neisserial L7 lipooligosaccharide (LOS) are bactericidal for L3,7 and L2,4 meningococci in the presence of human complement. These strains share a lacto-N-neotetraose (nLc4) LOS α chain. We used a set of mutants that have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens
Share to Carbohydrate Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Communicable Diseases

Share to Immunoglobulin G

Share to Meningococcal Vaccines

Share to Neisseria meningitidis

Share to Oligonucleotides

Share to Oligosaccharides

Source

Open in PubMed Open full text

Identifiers

PMID: 22027827
DOI: 10.1074/jbc.M111.291583
PMCID: PMC3243514

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human lipooligosaccharide IGG that prevents endemic meningococcal disease recognizes an internal lacto-N-neotetraose structure.PMID 22027827Read ↗

Neisserial Lipooligosaccharide Is a Target for Complement Component C4bSemantic proximity Read ↗

Immunologic and genetic characterization of lipooligosaccharide variants in a Neisseria meningitidis serogroup C strain.Semantic proximity Read ↗

Role of lgtC in Resistance of Nontypeable Haemophilus influenzae Strain R2866 to Human SerumSemantic proximity Read ↗

Functional characterization of an isogenic meningococcal alpha-2,3-sialyltransferase mutant: the role of lipooligosaccharide sialylation for serum resistance in serogroup B meningococci.Semantic proximity Read ↗

Genetically Modified L3,7 and L2 Lipooligosaccharides from Neisseria meningitidis Serogroup B Confer a Broad Cross-Bactericidal ResponseSemantic proximity Read ↗

Novel blocking human IgG directed against the pentapeptide repeat motifs of Neisseria meningitidis Lip/H.8 and Laz lipoproteins.Semantic proximity Read ↗

The (α2→8)-Linked Polysialic Acid Capsule and Lipooligosaccharide Structure Both Contribute to the Ability of Serogroup B<i>Neisseria meningitidis</i>To Resist the Bactericidal Activity of Normal Human SerumSemantic proximity Read ↗

Defining Targets for Complement Components C4b and C3b on the Pathogenic NeisseriaeSemantic proximity Read ↗

The glycointeractome of serogroup B Neisseria meningitidis strain MC58.Semantic proximity Read ↗

Tn916-generated, lipooligosaccharide mutants of Neisseria meningitidis and Neisseria gonorrhoeae.Semantic proximity Read ↗

The contrasting mechanisms of serum resistance of Neisseria gonorrhoeae and group B Neisseria meningitidisSemantic proximity Read ↗

Relative contributions of lipooligosaccharide inner and outer core modifications to nontypeable Haemophilus influenzae pathogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.