Article
Complement factor C3 deposition and serum resistance in isogenic capsule and lipooligosaccharide sialic acid mutants of serogroup B Neisseria meningitidis.
Infection and immunity - 1 Oct 1997
Vogel U, Weinberger A, Frank R, Müller A, Köhl J, Atkinson J P, Frosch M
Abstract excerpt
Serogroup B meningococci express sialic acids on their surfaces as a modification of the lipooligosaccharide (LOS) and as capsular material consisting of alpha2,8-linked sialic acid homopolymers. The aim of this study was to elucidate the impact of each sialic acid component on the deposition of...
Topics
- Bacterial Capsules
- Blood Bactericidal Activity
- Complement C3
- Complement C3b
- Humans
- Lipopolysaccharides
- Mutation
- N-Acetylneuraminic Acid
- Neisseria meningitidis
- Sialyltransferases
- UDPglucose 4-Epimerase