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Article

Sialic acid in the lipopolysaccharide of Haemophilus influenzae: strain distribution, influence on serum resistance and structural characterization.

Molecular microbiology - 1 Aug 1999

Hood D W, Makepeace K, Deadman M E, Rest R F, Thibault P, Martin A, Richards J C, Moxon E R

Abstract excerpt

A survey of Haemophilus influenzae strains indicated that around one-third of capsular strains and over two-thirds of non-typeable strains included sialic acid in their lipopolysaccharides (LPS). Mutation of the CMP-Neu5Ac synthetase gene (siaB) resulted in a sialylation-deficient phenotype. Isogenic pairs, wild type and siaB mutant of two non-typeable strains were used to demonstrate that sialic acid influences...

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PMID: 10447878
DOI: 10.1046/j.1365-2958.1999.01509.x

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