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Article

Cardiolipin is not essential for the growth of Saccharomyces cerevisiae on fermentable or non-fermentable carbon sources.

Molecular microbiology - 1 Nov 1997

Jiang F, Rizavi H S, Greenberg M L

Abstract excerpt

Cardiolipin is a unique dimeric phospholipid, which is present throughout the eukaryotic kingdom and is specifically localized in mitochondrial membranes. It is widely believed that mitochondria possess an essential requirement for this phospholipid. To determine whether cardiolipin is essential for yeast growth, we generated a cardiolipin synthase null mutant by disrupting the CLS1 gene (open reading frame...

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Identifiers

PMID: 9402019
DOI: 10.1046/j.1365-2958.1997.5841950.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cardiolipin is not essential for the growth of Saccharomyces cerevisiae on fermentable or non-fermentable carbon sources.PMID 9402019Read ↗

The PEL1 gene (renamed PGS1) encodes the phosphatidylglycero-phosphate synthase of Saccharomyces cerevisiae.Semantic proximity Read ↗

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Multicopy suppressors of phenotypes resulting from the absence of yeast VDAC encode a VDAC-like protein.Semantic proximity Read ↗

Synthetic lethal interaction of the mitochondrial phosphatidylethanolamine and cardiolipin biosynthetic pathways in Saccharomyces cerevisiae.Semantic proximity Read ↗

Absence of cardiolipin results in temperature sensitivity, respiratory defects, and mitochondrial DNA instability independent of pet56.Semantic proximity Read ↗

Cks1 is dispensable for survival in Saccharomyces cerevisiae.Semantic proximity Read ↗

Cardiolipin remodeling maintains the inner mitochondrial membrane in cells with saturated lipidomesSemantic proximity Read ↗

Cardiolipin molecular species with shorter acyl chains accumulate in Saccharomyces cerevisiae mutants lacking the acyl coenzyme A-binding protein Acb1p: new insights into acyl chain remodeling of cardiolipin.Semantic proximity Read ↗

Discovery of a cardiolipin synthase utilizing phosphatidylethanolamine and phosphatidylglycerol as substrates.Semantic proximity Read ↗

Deficiency of cardiolipin synthase causes abnormal mitochondrial function and morphology in germ cells of Caenorhabditis elegans.Semantic proximity Read ↗

Effect of low temperature upon vitality of Saccharomyces cerevisiae phospholipid mutants.Semantic proximity Read ↗

Cardiolipin biosynthesis and mitochondrial respiratory chain function are interdependent.Semantic proximity Read ↗

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