Article
Correlation between the functional assay for activated protein C resistance and factor V Leiden in the neonate.
Pediatric research - 1 Dec 1997
Sifontes M T, Nuss R, Hunger S P, Jacobson L J, Waters J, Manco-Johnson M J
Abstract excerpt
A factor V506 Arg-Gln mutation is the most common inherited cause of thrombophilia in adults. To date, there are no data regarding the detection of this mutation in neonatal blood or the relationship of this dysfunctional factor V to neonatal thrombosis. This study compared a modified activated protein C resistance functional assay with the PCR-based DNA assay for the factor V mutation in 115 prospectively...
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