Article
Therapeutic targeting of mutant p53 in pediatric acute lymphoblastic leukemia.
Haematologica - 1 Jan 2020
Demir Salih, Boldrin Elena, Sun Qian, Hampp Stephanie, Tausch Eugen, Eckert Cornelia, Ebinger Martin, Handgretinger Rupert, Kronnie Geertruy Te, Wiesmüller Lisa, Stilgenbauer Stephan, Selivanova Galina, Debatin Klaus-Michael, Meyer Lüder Hinrich
Abstract excerpt
Alterations of the tumor suppressor gene TP53 are found in different cancers, in particular in carcinomas of adults. In pediatric acute lymphoblastic leukemia (ALL), TP53 mutations are infrequent but enriched at relapse. As in most cancers, mainly DNA-binding domain missense mutations are found, resulting in accumulation of mutant p53, poor therapy response, and inferior outcome. Different strategies to target...
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