Article
N-acetyltransferase 2 genotype modification of active cigarette smoking on breast cancer risk among hispanic and non-hispanic white women.
Toxicological sciences : an official journal of the Society of Toxicology - 1 Nov 2009
Baumgartner Kathy B, Schlierf Thomas J, Yang Dongyan, Doll Mark A, Hein David W
Abstract excerpt
While it has been demonstrated that cigarette smoke contains aromatic and heterocyclic amines that initiate carcinogenesis, the association between cigarette smoking and breast cancer remains controversial. N-acetyltransferase 2 (NAT2) catalyzes arylamine carcinogen biotransformation and NAT2 genetic polymorphisms may contribute to differential susceptibility to breast cancer. We tested whether NAT2 modified the...
Topics
- Adult
- Aged
- Arylamine N-Acetyltransferase
- Breast Neoplasms
- Case-Control Studies
- Female
- Genotype
- Hispanic or Latino
- Humans
- Middle Aged
- Risk Factors
- Smoking
- Nicotiana
- White People