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Article

Regulation of number and size of digits by posterior Hox genes: a dose-dependent mechanism with potential evolutionary implications.

Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 1997

Zákány J, Fromental-Ramain C, Warot X, Duboule D

Abstract excerpt

The proper development of digits, in tetrapods, requires the activity of several genes of the HoxA and HoxD homeobox gene complexes. By using a variety of loss-of-function alleles involving the five Hox genes that have been described to affect digit patterning, we report here that the group 11, 12, and 13 genes control both the size and number of murine digits in a dose-dependent fashion, rather than through a...

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Identifiers

PMID: 9391088
DOI: 10.1073/pnas.94.25.13695
PMCID: PMC28368

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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