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Article

TIMP-1 promotes age-related renal fibrosis through upregulating ICAM-1 in human TIMP-1 transgenic mice.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Nov 2006

Zhang Xueguang, Chen Xiangmei, Hong Quan, Lin Hongli, Zhu Hanyu, Liu Qingxin, Wang Jianzhong, Xie Yuansheng, Shang Xiyao, Shi Suozhu, Lu Yang, Yin Zhong

Abstract excerpt

Imbalance of matrix metalloproteinases and tissue inhibitors of metalloproteinases (MMPs/TIMPs) takes part in age-related renal fibrosis; so does molecular inflammation. As several inflammatory mediators including intercellular adhesion molecule-1 (ICAM-1) are substrates of MMPs, we speculated th...

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Identifiers

PMID: 17167153
DOI: 10.1093/gerona/61.11.1130

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17167153-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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TIMP-1 promotes age-related renal fibrosis through upregulating ICAM-1 in human TIMP-1 transgenic mice.PMID 17167153Read ↗

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