Article
Effects of an inducible anti-sense c-myc gene transfer in a drug-resistant human small-cell-lung-carcinoma cell line.
International journal of cancer - 14 Nov 1997
Van Waardenburg R C, Meijer C, Burger H, Nooter K, De Vries E G, Mulder N H, De Jong S
Abstract excerpt
Small-cell-lung-cancer (SCLC) is characterized by rapid development of resistance to cytotoxic agents, such as cisplatin (cDDP) and anthracyclines. c-myc over-expression is one of the reported genetic alterations in this tumor. Amplification of the c-myc gene in this and other cancers is often correlated with poor prognosis. We studied the existence of a correlation between resistance and activation of the c-myc...
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