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Article

The Association of the Cholesterol Efflux Capacity with the Paraoxonase 1 Q192R Genotype and the Paraoxonase Activity.

Journal of atherosclerosis and thrombosis - 1 Sept 2024

Oniki Kentaro, Ohura Kayoko, Endo Megumi, Akatwijuka Daniel, Matsumoto Erika, Nakamura Teruya, Ogata Yasuhiro, Yoshida Minoru, Harada-Shiba Mariko, Saruwatari Junji, Ogura Masatsune, Imai Teruko

Abstract excerpt

AIMS: Paraoxonase 1 (PON1) binds to high-density lipoprotein (HDL) and protects against atherosclerosis. However, the relationship between functional PON1 Q192R polymorphism, which is associated with the hydrolysis of paraoxon (POXase activity) and atherosclerotic cardiovascular disease (ASCVD), remains controversial. As the effect of PON1 Q192R polymorphism on the HDL function is unclear, we investigated the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38508740
DOI: 10.5551/jat.64711
PMCID: PMC11374542

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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