Effects of the A117V mutation on the folding and aggregation of palindromic sequences (PrP113-120) in prion: insights from replica exchange molecular dynamics simulations.

Abstract excerpt

The palindromic region AGAAAAGA (PrP113-120) in prion is highly amyloidogenic and very critical in the structural conversion of cellular prion protein to its pathogenetic form. In this region, there is an important point mutation A117V, which is closely related to the occurrence of Gerstmann-Straussler-Scheinker Syndrome. However, the detailed knowledge about the effects of the A117V mutation on the folding and...

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