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Article

Genotypic selection of mutated DNA sequences using mismatch cleavage analysis, a possible basis for novel mutation assays.

Mutagenesis - 1 Sept 1997

Kortenkamp A, Jones C, Baker J

Abstract excerpt

A novel technique for the selection of mutated DNA sequences, termed mismatch cleavage-polymerase chain reaction (MC-PCR), is proposed. The method is based on hybridizing genomic DNA with a suitable probe, several 100 bp long. Mutated DNA sequences will form mismatched heteroduplexes which are cleaved by using resolvases. Cleaved heteroduplexes are detected by ligation to an oligonucleotide adaptor and then...

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Identifiers

PMID: 9379911
DOI: 10.1093/mutage/12.5.335

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genotypic selection of mutated DNA sequences using mismatch cleavage analysis, a possible basis for novel mutation assays.PMID 9379911Read ↗

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