Article
The association of HLA-DR alleles and T cell activation with allergic bronchopulmonary aspergillosis.
Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 1997
Chauhan B, Santiago L, Kirschmann D A, Hauptfeld V, Knutsen A P, Hutcheson P S, Woulfe S L, Slavin R G, Schwartz H J, Bellone C J
Abstract excerpt
Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity lung disease caused by the mold Aspergillus fumigatus. We previously reported that the majority of T cell clones (TCC) isolated from three ABPA patients, and specific for a dominant Ag of A. fumigatus, Asp f 1, were IL-4-producing CD4+ Th2 cells capable of responding to Ag in association with the HLA-DR subtypes DRB1*1501, *1503, and *1601 for...
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