Article
Evidence for the involvement of two different MHC class II regions in susceptibility or protection in allergic bronchopulmonary aspergillosis.
The Journal of allergy and clinical immunology - 1 Oct 2000
Chauhan B, Santiago L, Hutcheson P S, Schwartz H J, Spitznagel E, Castro M, Slavin R G, Bellone C J
Abstract excerpt
BACKGROUND: Allergic bronchopulmonary aspergillosis (ABPA) is a disease with uncertain pathology. Studies have suggested a pathogenic role for T(H)2 cells. Previously, we demonstrated, in a small group of patients, that T(H)2 reactivity to a major Aspergillus fumigatus antigen was restricted by HLA-DR2 or HLA-DR5 alleles. OBJECTIVES: We sought to confirm whether susceptibility to ABPA is exclusively associated...
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