Article
Defective actin reorganization and polymerization of Wiskott-Aldrich T cells in response to CD3-mediated stimulation.
Blood - 15 Oct 1997
Gallego M D, Santamaría M, Peña J, Molina I J
Abstract excerpt
The Wiskott-Aldrich syndrome (WAS) is a severe immunodeficiency and platelet deficiency disease arising from mutation(s) in the WASP gene, which in normal cells encodes an intracellular protein able to interact with other proteins relevant to the control of cytoskeleton organization. Immunodefici...
Topics
- Actins
- CD3 Complex
- Cell Division
- Cells, Cultured
- Cytoskeleton
- Gene Expression Regulation
- Herpesvirus 2, Saimiriine
- Humans
- Lymphocyte Activation
- Microscopy, Electron, Scanning
- Phenotype
- Polymers
- Protein Conformation
- Surface Properties
- T-Lymphocytes
- Wiskott-Aldrich Syndrome