Article
T cell lines characterize events in the pathogenesis of the Wiskott-Aldrich syndrome.
The Journal of experimental medicine - 1 Sept 1992
Molina I J, Kenney D M, Rosen F S, Remold-O'Donnell E
Abstract excerpt
The Wiskott-Aldrich syndrome (WAS) is a severe immunodeficiency and platelet deficiency disease arising from an X-linked defect. The disease is correctable by transplantation of hematopoietic stem cells, but the product of the defective gene is unidentified and the number of defects in patient blood cells is large. The current hurdle is the need to identify the early pathogenic event(s) that are the cause of...
Topics
- Adolescent
- Adult
- Blotting, Western
- Child
- Flow Cytometry
- Humans
- Infant
- Lymphocyte Activation
- Microscopy, Electron, Scanning
- Phenotype
- T-Lymphocytes
- Up-Regulation