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Neuromuscular function impairment is not caused by motor neurone loss in FALS mice

1 May 1996

Abstract excerpt

Dominant mutations of human Cu/Zn superoxide dismutase (SOD1) are found in about 20% of patients with familial amyotrophic lateral sclerosis (FALS). A transgenic mouse model of FALS (FALSG93A mice) has been generated by overexpression of a mutated form of SOD1. Using electromyography we first show that FALSG93A mice suffer from motoneurone dysfunction similar to that observed in ALS patients and fulfill Lambert's...

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PMID: 8856691
DOI: 10.1097/00001756-199605310-00021

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