Article
Measurement of cytotoxic T lymphocyte precursor frequencies reveals cryptic HLA class I mismatches in the context of unrelated donor bone marrow transplantation.
Transplantation - 15 Nov 1997
O'Shea J, Madrigal A, Davey N, Brookes P, Scott I, Firman H, Lechler R, Goldman J, Batchelor R
Abstract excerpt
BACKGROUND: In this large, two-center study, 260 cytotoxic T lymphocyte precursor (CTLp) frequency assays, performed to assess patient-donor compatibility, were analyzed in relation to the degree of HLA matching. METHODS: While the tissue-typing techniques used at the Royal Postgraduate Medical S...
Topics
- Bone Marrow Transplantation
- Hematopoietic Stem Cells
- Histocompatibility Antigens Class I
- Histocompatibility Antigens Class II
- Humans
- Isoelectric Focusing
- Phenotype
- Polymerase Chain Reaction
- T-Lymphocytes, Cytotoxic
- Tissue Donors