Article
Deletions and rearrangements of cyclin-dependent kinase 4 inhibitor gene p16 are associated with poor prognosis in B cell non-Hodgkin's lymphomas.
Leukemia - 1 Nov 1997
García-Sanz R, González M, Vargas M, Chillón M C, Balanzategui A, Barbón M, Flores M T, San Miguel J F
Abstract excerpt
In the present study we examined by Southern blot analysis the presence of deletions and rearrangements of the p16 tumor-suppressor gene in B cell non-Hodgkin's lymphomas (NHLs) in order to determine whether or not these changes can be related to a particular histological subtype and the different clinico-biological and prognostic characteristics of the disease. 103 untreated patients were enrolled in the study....
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