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Article

Overall survival in aggressive B-cell lymphomas is dependent on the accumulation of alterations in p53, p16, and p27.

The American journal of pathology - 1 Jul 2001

Sánchez-Beato M, Sáez A I, Navas I C, Algara P, Sol Mateo M, Villuendas R, Camacho F, Sánchez-Aguilera A, Sánchez E, Piris M A

Abstract excerpt

Different studies have already shown that the isolated inactivation of p21, p16, or p27 cyclin-dependent kinase inhibitors (CKIs) is associated with increased growth fraction, tumor progression, or decreased overall survival in cases of non-Hodgkin's lymphoma. In this study we linked molecular study of the p53 and p16 genes with immunohistochemical analysis of p27 expression in a group of aggressive B-cell...

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Share to Chromosomes, Human, Pair 9
Share to Cyclin-Dependent Kinase Inhibitor p27

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Silencing

Share to Genes, p16

Share to Genes, p53

Share to Lymphoma, B-Cell

Share to Methylation

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Source

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Identifiers

PMID: 11438467
DOI: 10.1016/S0002-9440(10)61686-0
PMCID: PMC1850429

Genes

CDK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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