Article
The inactivation of the XP-C gene does not affect somatic hypermutation or class switch recombination of immunoglobulin genes.
Molecular immunology - 1 May 1997
Shen H M, Cheo D L, Friedberg E, Storb U
Abstract excerpt
The mechanism of somatic hypermutation of immunoglobulin genes is not known, but appears to be linked to transcription and perhaps DNA repair. In order to determine if global DNA repair or the repair of the nontranscribed DNA strand is required for somatic mutation, we have analysed mice whose XP-C gene was inactivated by homologous recombination. Our study shows that hypermutation occurs in XP-C knockout mice...
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