Article
Search for DNA sequence variations using a MutS-based technology.
Mutation research - 1 Sept 1997
Bellanné-Chantelot C, Beaufils S, Hourdel V, Lesage S, Morel V, Dessinais N, Le Gall I, Cohen D, Dausset J
Abstract excerpt
The search for DNA sequence variations (DSV) is emphasized with genetic studies of a large number of multifactorial diseases. Saturation of regions of interest with diallelic polymorphisms will be an essential step to pinpoint, through association studies, predisposing genes. We have developed a solid-phase method based on the ability of mismatch binding protein MutS to recognize single nucleotide mismatches....
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