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Article

The effects of anagrelide on human megakaryocytopoiesis

1 Oct 1997

Abstract excerpt

Anagrelide, an inhibitor of platelet aggregation, decreases the number of platelets in normal subjects and in patients with myeloproliferative disorders. We describe studies aimed at discovering the general mechanism(s) by which anagrelide acts. We examined three hypotheses: (1) anagrelide shortens platelet survival, (2) anagrelide inhibits the proliferation of megakaryocytic-committed progenitor cells (CFU-M),...

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PMID: 9359521
DOI: 10.1046/j.1365-2141.1997.3503164.x

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