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Article

Erythrocyte G Protein-Coupled Receptor Signaling in Malarial Infection

18 Sept 2003

Abstract excerpt

Erythrocytic mechanisms involved in malarial infection are poorly understood. We have found that signaling via the erythrocyte beta2-adrenergic receptor and heterotrimeric guanine nucleotide-binding protein (Galphas) regulated the entry of the human malaria parasite Plasmodium falciparum. Agonists that stimulate cyclic adenosine 3',5'-monophosphate production led to an increase in malarial infection that could be...

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PMID: 14500986
DOI: 10.1126/science.1089324

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