Role of the constriction loop in the gating of outer membrane porin PhoE of Escherichia coli.

doi:10.1016/s0014-5793(97)01150-2

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Article

Role of the constriction loop in the gating of outer membrane porin PhoE of Escherichia coli.

FEBS letters - 6 Oct 1997

Eppens E F, Saint N, Van Gelder P, van Boxtel R, Tommassen J

Abstract excerpt

Porins form voltage-gated channels in the bacterial outer membrane. These proteins are composed of three identical subunits, each forming a 16-stranded beta-barrel. In this study, the role in voltage gating of a loop that forms a constriction within the pore was studied. The channel characteristi...

Topics

Anti-Bacterial Agents
Cloning, Molecular
Electric Conductivity
Escherichia coli
Escherichia coli Proteins
Ion Channel Gating
Lactams
Liposomes
Models, Molecular
Mutation
Porins
Protein Conformation
Protein Structure, Secondary

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