Article
Strong balancing selection at HLA loci: evidence from segregation in South Amerindian families.
Proceedings of the National Academy of Sciences of the United States of America - 11 Nov 1997
Black F L, Hedrick P W
Abstract excerpt
The genotypic proportions for major histocompatibility complex loci, HLA-A and HLA-B, of progeny in families in 23 South Amerindian tribes in which segregation for homozygotes and heterozygotes could occur are examined. Overall, there is a large deficiency of homozygotes compared with Mendelian expectations (for HLA-A, 114 observed and 155.50 expected and for HLA-B 110 observed and 144.75 expected), consistent...
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