Strong balancing selection at HLA loci: evidence from segregation in South Amerindian families.

doi:10.1073/pnas.94.23.12452

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Article

Strong balancing selection at HLA loci: evidence from segregation in South Amerindian families.

Proceedings of the National Academy of Sciences of the United States of America - 11 Nov 1997

Black F L, Hedrick P W

Abstract excerpt

The genotypic proportions for major histocompatibility complex loci, HLA-A and HLA-B, of progeny in families in 23 South Amerindian tribes in which segregation for homozygotes and heterozygotes could occur are examined. Overall, there is a large deficiency of homozygotes compared with Mendelian e...

Topics

Alleles
Biological Evolution
Female
HLA-A Antigens
HLA-B Antigens
Heterozygote
Homozygote
Humans
Male
Models, Theoretical
Polymorphism, Genetic
South America

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