Article
Differentiation between African populations is evidenced by the diversity of alleles and haplotypes of HLA class I loci.
Tissue antigens - 1 Apr 2004
Cao K, Moormann A M, Lyke K E, Masaberg C, Sumba O P, Doumbo O K, Koech D, Lancaster A, Nelson M, Meyer D, Single R, Hartzman R J, Plowe C V, Kazura J, Mann D L, Sztein M B, Thomson G, Fernández-Viña M A
Abstract excerpt
The allelic and haplotypic diversity of the HLA-A, HLA-B, and HLA-C loci was investigated in 852 subjects from five sub-Saharan populations from Kenya (Nandi and Luo), Mali (Dogon), Uganda, and Zambia. Distributions of genotypes at all loci and in all populations fit Hardy-Weinberg equilibrium expectations. There was not a single allele predominant at any of the loci in these populations, with the exception of...
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